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Alderton W, Berghmans S, Butler P, Chassaing H, Fleming A, Golder Z, Richards F and Gardner I 2010 Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae

Key insights from the review: Rapid growth of the field since 2019, led by the US, China, and Germany Strong focus on #stroke, #Alzheimers disease, #Parkinsons disease, and bioactive compounds from traditional Chinese medicine Identification of core molecular hubs: STAT3, IL6, TP53, AKT1, and JUN Major mechanistic hotspots include apoptosis, NLRP3 inflammasome, microglial polarization, and NF-B/JAK-STAT/PI3K-AKT pathways Why it matters The analysis highlights a paradigm shift away from one drugone target approaches toward multi-target, systems-level therapeutic strategies, better aligned with the multifactorial nature of neuroinflammatory CNS diseases

Recognizing the molecular variability evident in diabetic heart failure patients [17], we methodically structured our experiment, meticulously matching age, sex, and race between the diabetic and healthy cohorts