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Retrieved from doi:10.1101/cshperspect.a005686

6.2 Folates and ASD Folic acid, folinic acid and 5-methylenetetrahydrofolate are folates, which are essential for the metabolism of nucleotides and DNA methylation

The liver alcohol dehydrogenase metabolizes the acetaldehyde of alcohol making this organ particularly susceptible to lesion ( The brain is mainly composed of lipids, particularly docosahexaenoic acid (DHA) (22:6n-3), a n-3 long-chain polyunsaturated FA (PUFA), and eicosapentaenoic acid (EPA, 20:5n-3) and, at lower levels, by the omega-6 (n-6) arachidonic acid (AA) (28) impairs synaptic plasticity (2931), particularly N-methyl-D-aspartate (NMDA)-dependent long-term potentiation (LTP) in the hippocampus (31) and medial prefrontal cortex (30), two brain regions enriched with DHA (32)