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Initially identified as nine fundamental biological drivers of aging (13), the list has been updated to include twelve hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis (14)

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STEP 3 showed 16.0% with intensive lifestyle intervention

The Regulatory and Legal Reality In 2023, the FDA classified BPC-157 as a Category 2 bulk drug substance