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This receptor works to clear IGF-II and its presence in endothelial cells may, at least partly, explain the lack of endocrine actions of IGF-II due to its proteolytic lysosomal degradation (23)
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In these ways, mitochondria contribute to various diseases, including tumors, cardiovascular diseases, neurodegenerative diseases, metabolic abnormalities, ocular diseases, liver diseases, and autoimmune diseases, by inducing mitochondrial dysfunction or through regulating oxidative stress, inflammation, and aging
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