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We have shown that the 'stemness' of these cells is maintained through the combined action of a Niche Signal, generated by Hedgehog (Hh) (Mandal et al., Nature, 2007), a local signal generated by Wingless/Wnt (Sinenko et al., Dev

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HildebrandtMHoffmannCSherrill-MixSKeilbaughSHamadyMChenYet alHigh-fat diet determines the composition of the murine gut microbiome independently of obesity

Furthermore, stringent iron histochemistry together with transcriptomic analyses suggest that the AD brain contains a higher proportion of tightly bound/sequestered iron pools, and that anemialike and iron metabolism-related transcriptional changes emerge early, supporting a functional iron deficiency hypothesis