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Using MTX may be associated with intestinal mucous membrane damage as well as mucositis, which impairs the ability of patients to tolerate treatment and disturbs their nutritional status

Gliotoxin was administrated to female C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein with a dose of 1 mg/kg, which can aggravate the symptom of neuroinflammation via the upregulation of inflammatory genes, including T-box transcription factor (TBX21), inducible nitric oxide synthase (iNOS), arginase 1 (ARG1), and cytokines such as IFN-, IL-17, and IL-2 [48]

[9] Glycerol 3-phosphate + NAD + DHAP + NADH + H + During prolonged fasting , glycerol becomes the major gluconeogenic precursor , accounting for approximately 20% of total glucose production

PLoS ONE 12 , e0168234 (2017)