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Description
Kamath BM, Podkameni G, Hutchinson AL, Leonard LD, Gerfen J, Krantz ID, Piccoli DA, Spinner NB, Loomes KM, Meyers K

10.1212/WNL.0000000000005254 67 Dinis-OliveiraR

The accumulation of ROS prevents Nrf2 from being ubiquitinated by modifying the cysteine in Keap1, allowing Nrf2 to be expressed stably in the nucleus and activating the antioxidant reaction elements (ARE), which include the expression of a series of antioxidant genes such as GSH, GCL, HMOX , and GSL (46)

La direzione della regolazione e in questo caso caratteristica
