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In humans, it has been observed that VIC may prevent the onset of osteoarthritis, but also vice versa, with high concentrations of VIC being associated with an increased risk of developing osteoarthritis [117] and VIC did not prevent damage to cartilage structure [117,118]

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Am J Manag Care 20:S128-135 Gill N, Ferreira RBR, Antunes LCM et al (2012) Neutrophil elastase alters the murine gut microbiota resulting in enhanced Salmonella colonization