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demonstrating reduced activity of mammalian target of rapamycin complex 2 (mTORC2) in brain tissue from individuals with AD
Mechanistically, NAD+ replenishment was found to counteract the OGD-induced accumulation of oxidative DNA damage, including AP sites and single/double-strand breaks
Indeed, the measurement of serum methionine and methylmalonic acid in cases of homocysteinemia (homocystinuria) allows for a differential diagnosis of the nutritional (non-genetic) cause
Peroxidation of lipids affects the membrane fluidity of neurons and consequently the transport of neurotransmitters (Barber and Raben 2019)
