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Lezak, K

They are among the most clinically studied peptides in modern medicine

Copper causes cuproptosis by binding to lipid-acylated components of the tricarboxylic acid cycle, leading to protein aggregation, loss of iron-sulfur cluster proteins, and eventually proteotoxic stress

The different outcomes can be explained on the one hand due to the different host environments, namely intact retinas (Kinouchi et al., 2003) or intact hippocampi on the Rag-1 knock-out background (Widestrand et al., 2007), compared to ischemic cortical stroke combined with immunosuppression by cyclosporine A (Laterza et al., 2018)
