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Description
Cytokines suppress erythropoiesis in multiple ways including: Decreased iron availability from decreased absorption (mostly due to cytokine-mediated upregulation of hepcidin, a protein which inhibits iron absorption) and iron sequestration within macrophages (due to increased iron uptake and storage from cytokine-mediated stimulation of ferritin production and hepcidin-mediated decreased iron export in cells

Fine LM, Bernstein JA

Furthermore, OS has been postulated to be an important mechanism underlying obesity-related MetS (125)

Timing & Dosage Considerations Split Dosing: Many protocols divide the daily dose into two or three smaller administrations to maintain steady blood levels
