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Ethical statement The experimental design and reporting followed the ARRIVE guidelines to ensure transparency and reproducibility

Neuroinflammation As neuroinflammation has been suggested to be responsible for other fatigue-related neurologic diseases, such as multiple sclerosis [118], neuroinflammation has also been hypothesized to contribute to ME/CFS

Overall, the observed patterns were primarily related to amino acid metabolism, lipid metabolism, and neurotransmitter-associated pathways, suggesting pathway-level metabolic alterations in ASD

Hot Drink: Empty 1 sachet into a cup, add 120 ml hot water, stir well, and enjoy