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Excludes1 (do not code together) Excludes1 means mutually exclusive. Conditions with distinct definitions must not be reported with M62.81 when the excludes rule applies

Several of the changes observed in connective tissue are thought to reflect variations in the levels of MMPs, the enzymes involved in regulating and maintaining the extracellular matrix that degrade extracellular matrix molecules, proteoglycans, elastin, and different types of collagens [109]

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