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But if you come back every week for a month or so you'll notice a big difference in your overall level of energy." So the very first time someone gets a B12 shot they probably won't feel much of an effect, even though they might experience a bit of an energy boost after the very first one, but it usually only lasts for about a week

Org Lett 2003, 5 (6), 933936

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[5] Post introduction, it is suggested that IGF-I levels could remain elevated for at least 2 weeks in test models receiving greater exposure