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Angioedema can be life-threatening if swelling of the tongue or in the throat blocks the airway

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Exogenous stimulation causes the accumulation of NIK(NF-B binding kinase), which co-interacts with IKK to promote the phosphorylation of p100 and further processing into p52, promoting RelB/p52 heterodimer to enter the nucleus and activate related target genes, thus accelerating the development of multilayer immune cells

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