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They interact with G-protein-coupled receptors, ion channels, or internal cellular machinery to exert diverse effects, including hormonal stimulation, angiogenesis, mitochondrial regulation, or immune modulation

This process promotes the sequestration of calcium ions in the sarcoplasmic reticulum while reducing their concentration in the cytosol, which impacts phosphorylation and consequently results in smooth muscle relaxation (Fig

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This study is the first to integrate the MGBA theory with VNS technology, revealing its cross-system regulatory network in intervening PD and providing new ideas for breaking through the limitations of traditional treatments