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Methylmalonic acid (MMA) and homocysteine : These biomarkers rise when B12 levels are low, often before serum B12 drops, helping to detect deficiencies

A.CardosoF

Graphical abstract Similar content being viewed by others The importance of autophagy in cell homeostasis Autophagy and the ubiquitin proteasome system (UPS) are two major intracellular degradative mechanisms that mediate the catabolism of proteins and organelles

Nature 423 (6937), 293298