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Li XF, Wang ZQ, Zhu L, et al

Once stabilized, HIF- translocates to the nucleus, dimerizes with HIF-1/Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT), and forms a HIF transcription factor to promote cellular pathways influencing proliferation and malignant progression (39, 156158, 164)

And Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Science

MTHFR converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the cofactor form necessary for the re-methylation of homocysteine to methionine (see Figure 2 above)