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However, a common observation in all of these studies is the critical role of posttranscriptional regulation: as in other tissues, a majority (78%) of rhythmic proteins were encoded by nonrhythmic mRNA

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110 Moreover, CDDP-resistant cancer cells may exhibit increased levels of GSH, the enzyme that catalyzes GSH synthesis (i.e., -glutamylcysteine synthetase), the enzyme that conjugates CDDP with GSH (i.e., glutathione S-transferase), or metallothioneins

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