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The sequence parameters included a TE of 80 ms, TR of 2,000 ms, water suppression using a multiple optimized insensitive suppression train, pulse duration of 20 ms, an estimated water peak of 4.68 ppm, editing pulses interleaved at 1.9 ppm (ON) and 1.5 ppm (OFF), averaging two signals, a phase cycle of 16, frequency stabilization, and a total of 160 dynamic scans

4g, Additional file 1: Fig

Future studies will validate in vivo modulation of WAT NAD + /SAM and delineate NAD + - and SAM-mediated epigenetic mechanisms that may underlie gene regulation in the presence of NNMT inhibitors

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