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Description
Abbreviations KOA: Knee osteoarthritis LPS: Lipopolysaccharide FLS: Fibroblast-like synoviocytes AMPK: AMP-activated protein kinase CPT1: Carnitine palmitoyltransferase 1 Cyc: Cytochrome c ACLT: Anterior cruciate ligament transection NSAIDs: Non-steroidal anti-inflammatory drugs CoA: Coenzyme A SOD: Superoxide dismutase MDA: Malonaldehyde ATP: Adenosine-triphosphate ROS: Reactive oxygen species CCK-8: Cell counting kit-8 DMEM: Dulbeccos modified Eagles medium IL-1: Interleukin-1 siRNA: Small interfering RNA References Sharma L

Activation of TGR5 restores AQP2 expression via the HIF pathway in renal ischemia-reperfusion injury


Untreated, it usually leads to premature CAD (in women before 60 years of age, and in men before 55 years) which means an up to 10-fold increase in the risk of CAD [275]
