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According to the researchers, MK-677 treatment resulted in sustained increases in lean body mass and a temporary increase in basal metabolic rate, levels suggesting that further study was needed to see if a higher dose of MK-677 or a longer treatment period would affect levels of body fat [7]

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Disulfide bonds formed by the oxidation of two cysteine residues to give cystine are essential for the stability of secreted and plasma-membrane proteins (reviewed in [18])