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However, this study utilized only M1 macrophages under in vitro conditions, further in-depth in vivo and in vitro studies are required to validate these observations by using macrophage reprogramming approaches, such as small molecules drugs or gene editing techniques

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Data availability In terms of data processed or generated as part of this study, we provide per-population mtDNA heteroplasmic and homoplasmic allele frequencies and counts in UKB and AoU (Supplementary Tables 5 and 6), genetic association statistics for LD-independent lead SNPs and fine-mapped variants in UKB in addition to colocalization results (Supplementary Tables 24) and gene-based RVAS association statistics for genes at GWS for the Cauchy test (Supplementary Table 7)