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Description
Chronic psycho-socioeconomic stress, early life adversity, depression, post-traumatic stress disorder, obesity, or prolonged use of sGCs are conditions usually associated with dysregulation of the HPA axis [4]

But using them together can affect treatment results

Trindade, E.A

Similar findings have been implicated in the pathogenesis of bipolar disorder, including the involvement of elevated free radicals such as NO, as well as lipid peroxidation and altered antioxidant levels (157, 162)
