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Code was written in Python (version 3.9.16) using the sci-kit learn package ( and is publicly available at Data availability Data associated with this study can be requested for the authors and will be made available at MetabolomicsWorkbench: Code availability The code for the machine learning pipeline is publicly available at custom scripts will be made available at GitHub

The injured liver, predominantly Kupffer cells and infiltrating macrophages and neutrophils, produces TNF-, interleukin-1 and interleukin-6

7 Conclusions and outlook Bilirubin has a complex interaction with cancer, and bilirubin can inhibit tumorigenesis and development through a variety of mechanisms, including influencing cellular redox reactions, signaling, and the immune system, while the effects of cancer on bilirubin have derived several prognostic models

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