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PGC-1 is a transcriptional coactivator that interacts with several transcription factors to control the transcription of more than 150 genes encoding mitochondrial proteins involved in fatty acid oxidation, the tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS), the mitochondrial ribosomal machinery and membrane transport

Atorvastatin restores Lck expression and lipid raft-associated signaling in T cells from patients with systemic lupus erythematosus

[,] Importantly, carvedilol treatment preserved SH levels (245.9 41.75 mol/L), with values significantly higher than both the untreated I/R group ( P = 0.002) and approaching those of sham controls, suggesting effective interception of ROS before they could oxidize cellular thiols

E., Pocock, W