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It has been demonstrated that GGT is overexpressed in many human malignancies including primary GBMs, whereas GGT expression is low in normal brain astrocytes and neurons 4,15,16,17,18,19

Furthermore, one of the most important brain metabolic markers is N-acetyl-aspartate (NAA) which contributes to the production of energy by the mitochondria
Isotopic tracing of glutamine in MYCdriven liver tumors MYC activates expression of the glutamine transporter Slc1a5, which increases cellular uptake of glutamine 11, 12
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