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Did you use sterile technique during reconstitution

The downstream effects are dramatic: keratinocyte proliferation and differentiation accelerate, the epidermis compacts and normalizes, melanin transfer is disrupted (fading pigmentation), and dermal fibroblasts are stimulated to produce new collagen while matrix-degrading enzymes (MMPs) are suppressed

Cell Stress and Chaperones 5, 276290

If cloudiness or undissolved material persists, the vial should be allowed to sit at room temperature for several minutes before gently swirling again
