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no therapeutic intervention trials published Cell culture Skeletal muscle myoblasts, cardiomyocytes, endothelial cells, fibroblasts, mesenchymal stem cells Ex vivo tissue preparations Isolated mitochondria, cardiac tissue preparations for respiration studies Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 100 published preclinical studies and growing scientific interest, MOTS-c faces substantial translational barriers that limit clinical application and necessitate cautious interpretation of its therapeutic potential
Data processing and annotation of metabolites Raw data processing was performed using Progenesis QI software (V3.0.7600.27622) with METLIN TM plugin V1.0.7642.33805 (NonLinear Dynamics) and entailed peak picking, alignment, normalization, and database searching 62
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The Relative Significance of CO 2 Fixing Enzymes in the Metabolism of Rat Brain. Journal of Neurochemistry 22: 717724
