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Higher absolute bioavailability for hydroxychalcone may be due to its higher tissue binding, high molecular weight, higher water solubility, and higher volume of distribution

In practice, if the cytoprotection concept is valid as a general concept (cytoprotection organoprotection) [41,42,43,44,45,46,47,48,49] and the NO-system has general significance [189,190,191], they can serve each others functions accordingly via cytoprotection agent modulatory potential on NO-blockade/NO-over-activity/NO-immobilization

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Falutz J, Mamputu JC, Potvin D, et al.: Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: A pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data