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These pathways are activated following the binding of IL-13 to its receptor and the phosphorylation and translocation of STAT-6 to the nucleus
302 Notably, microbial metabolites produced by commensal gut flora can limit pathogenic activities of microglia and astrocytes and suppress CNS inflammation in MS experimental models 303 and can contribute to the induction of specific LAMP1+TRAIL+ astrocytes that limit CNS inflammation by inducing T cell apoptosis
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