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Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying

Inspite of promising preclinical and observational data, their clinical translation remains limited due to challenges in bioavailability, lack of standardization, and possible herbdrug interactions

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13 C NMR spectroscopy following 4 hour [(1,2- 13 C 2 )acetyl]-L-carnitine intravenous infusion showed that in the liver the acetyl groups enter the TCA cycle since 13 C was found in liver glutamate, glutamine, and glutathione and was incorporated into cholesterol and 3-hydroxybutyrate [115]
