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For individuals with digestive sensitivities, those taking acid-reflux medications, or anyone on a plant-based (vegan/vegetarian) diet, absorbing enough B12 through food or pills is virtually impossible

In a double-blind, randomised controlled trial of 3680 adults with non-disabling cerebral infarction, subjects who received a combination of vitamin B 6 , vitamin B 12 , and folic acid showed moderate reduction in total homocysteine levels, but there was no effect on vascular outcomes (recurrent ischaemic stroke and coronary heart disease) during 2 years of follow-up.49 Probably a longer duration of treatment may be necessary or there may be other factors governing the clinical response

Red blood cell production is disrupted when vitamin B12 levels are too low, resulting in megaloblastic anemia
