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Leukocytospermia, characterized by the presence of more than one million leukocytes per milliliter of semen, is a well-established contributor to male infertility

Functional characterization of hTrxR1 variants In order to study the impact of the guiding bar residues (Trp407 hTrxR1 , Asn418 hTrxR1 , and Asn419 hTrxR1 ) of hTrxR1 upon catalysis, we constructed two different mutants of hTrxR1: hTrxR1 N419A,U498C , and hTrxR1 W407A,N418/9A,U498C (Table 2)

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Synthesis and structureactivity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists