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Folate deficiency leads to the accumulation of homocysteine which is associated with an increased risk of cerebrovascular diseases, depression, and dementia, with a focus on vascular dementia and Alzheimers disease (, , )

When NNMT is inhibited: NAD+ levels rise Mitochondria become more efficient Cells burn more energy, even at rest This effect helps the body shift into a more metabolically active state, making it easier to reduce fat and preserve muscle during weight loss

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It should not be co-administered with drugs that are known to be strong CYP2C19 inhibitors, such as voriconazole and fluvoxamine