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Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H1 receptor and TRPV1

Y., Choi, J

So a holistic view is needed

In addition to its cardiovascular benefits, citrulline may improve skeletal muscle function and oxygen delivery by enhancing blood flow and reducing muscle fatigue, which could be particularly advantageous for postmenopausal women at risk of muscle loss and frailty [6, 11,12,13]
