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Similarly, the EMPA-KIDNEY trial, which included 6,609 participants across various CKD etiologies and stages, demonstrated that empagliflozin reduced the risk of kidney disease progression or renal death by 28% (HR 0.72

In addition, the results indicated essential roles of GPX in controlling ROS homeostasis by regulating intracellular H 2 O 2 levels, maintaining GSH/GSSG balance, and promoting antioxidant enzyme activity

However, the present study was bound to wellestablished drug concentrations able to significantly inhibit their targets

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