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Patients who have an additional mutation of the LZTR1 (leucine-zipperlike transcription regulator 1 gene) confers an increased risk of developing a VS.12 , 13 37.4 Staging and Presentation The functions of a staging system are twofold: First, to define criterion points in tumor growth and symptomatology that are associated with a significant change in outcome prognosis, so that patients can be given properly informed consent

The LPL dimerization interface resembles the GPIHBP1 binding interface and helical LPL interface We next examined the C-terminal to C-terminal LPL dimerization interface (Fig