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Accordingly, by controlling the balance between glutamate uptake and release, astrocytes have the ability to maintain glutamate homeostasis, support normal neuronal function, and protect against glutamate excitotoxicity

These changes can be reversible or persistent, and they play a central role in how diseases develop or are prevented across the lifespan

All those effects cause relevant changes in glial cell regulation and inflammatory activation, triggering chronic neuroinflammation and potentiating pathological aging