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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

For iron deficiency anaemia in pregnancy (a related issue), they have stated that it is not clear if pregnant women with mild to moderate IDA will benefit from treatment and theres a lack of evidence on benefits and harms associated with screening. Similar reasoning might apply to B12 deficiency in the absence of strong evidence of benefit from routine screening

Some people find they lose more weight when adding B12, especially if they had a B12 deficiency before starting