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By providing a strong, unmistakable signal of biological night, high-dose melatonin helps resynchronize the immune system's clock

This research strengthens the advantages derived from dendrimers, such as enhanced structural adaptability, stability, and mucosal penetration, as well as improved drug loading efficiency and sustained drug release (Suthar et al., 2025)
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These systemic effects are particularly effective in alleviating conditions like atopic dermatitis and improving hydration
