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163 Approximately 5060% of patients with DFUs develop diabetic foot infections, and 15% ultimately undergo amputation

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One hypothesis posits that pressor effects are mediated by the activation of central MC receptors but not peripheral, supported by observed cardiac effects after central -MSH administration but not when -MSH is delivered intravenously ( q pathway, may mitigate pressor effects while maintaining anorectic activity ( It is important to note that MC4R potency correlates well with observed clinical weight loss