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Description
Transit times in most normal microvascular beds are too short for significant aggregation of deoxygenated HbS to occur, and as a result sickling is confined to microvascular beds with slow transit times

Taoka et al, 1998)

Sep 7 2020;91(3):e2020085
There is considerable evidence that has demonstrated that TFs are important players involved in the genetic mechanisms of resistance 16,21,22,23,24,25
