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Managing the swelling is an important aspect of this as edema will slow the healing process and increase pain

[11] It results from a localized defect in the phrenoesophageal ligament while the gastroesophageal junction remains fixed to the preaortic fascia and the median arcuate ligament

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ROS levels of HCMECs treated with vehicle (Ctr), 100 M epinephrine (Epi), epinephrine plus 10 M SCH23390 (Epi+SCH), 10 M SKF38393 (SKF), 5 M fenoldopam (Fen), SKF 38393 plus 1 M apamin (SKF+Apa), SKF38393 plus SCH23390 (SKF+SCH)