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While the testis may not accept a large number of islets to restore normoglycemia (96), testis islet transplantation could be conducted as a pioneering procedure to induce peripheral tolerance and protect a second site that can receive enough size of the graft

Similarly, Berberine has been shown to inhibit CYP2D6 and CYP3A4, which can increase the risk of drug accumulation and toxicity when co-administered with tricyclic antidepressants, macrolide antibiotics, or calcium channel blockers

& Cunningham-Rundles, C
