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Oxidative stress is proposed as a major pathogenic mechanism in Alzheimers disease (Liu et al., 2004

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doi:10.1007/s00204-012-0924-1 Hinson JA, Roberts DW, James LP (2010) Mechanisms of acetaminophen-induced liver necrosis

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Individuals with this homozygous polymorphism may require not only folic acid supplementation but also active forms of folate

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