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Brown and beige adipocytes can be identified morphologically as multilocular and function to convert energy into heat through an uncoupling process that is largely mediated by uncoupling protein 1 (UCP1)

In addition to glycolysis, glutamine can fuel lactate production via its catabolic pathway, providing tumor cells with an auxiliary lactate-generating route that supports their highly glycolytic phenotype [63]

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Study strengths and limitations Strengths The extensive use of random patient sampling for the formation of study groups reduces the likelihood of biases or distortions resulting from the patient assignment