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During 1C metabolism, via the methylation cycle, Hcy is produced as an intermediate, and excess Hcy levels (i.e., HHcy) have been associated with the aging process via the induction of oxidative stress, lipid peroxidation, DNA damage, etc

Bin BH, Bhin J, Takaishi M, Toyoshima KE, Kawamata S, Ito K et al (2017) Requirement of zinc transporter ZIP10 for epidermal development: implication of the ZIP10-p63 axis in epithelial homeostasis

Building on this rationale, recent preclinical findings underscore the promise of combining targeted apoptosis inducers with cell-cycle inhibitors
