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Additionally, glutathione plays a crucial role in regenerating other antioxidants, such as vitamins C and E

In Atg7-deficient mice, the loss of autophagy in hematopoietic stem cells not only leads to increased aberrant myeloid expansion, resulting in severe myeloid dysplasia and infiltrating myeloid blast cells evoking AML [18] but can also activate the NOTCH signaling pathway, blocking HSC differentiation and leading to a leukemic phenotype [19]

Acid-sensing ion channels (ASICs), particularly ASIC1a and ASIC3, play a key role in this process (Swain et al., 2012

Seshacharyulu P, Baine MJ, Souchek JJ, Menning M, Kaur S, Yan Y, et al