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Glycogen synthase kinase 3(GSK3) phosphorylation inhibits its activity leading to the action of glycogen synthase

Through upregulating the mRNA levels of germ cell specific genes (e.g., DAZL, VASA, and PIWIL2), as well as meiotic genes (e.g., SCP3, Cyclin A1, and STRA8), HAM MSCs could increase protein expressions of survivin and Bcl-2, while reducing those of Capase3 and Capase9, thereby enhancing the anti-apoptotic ability of testicular tissue cells in mice, thus treating busulfan-induced damage to testicular tissues in mice (100)

Continuing treatment through plateaus often leads to further improvement

Conversely, individuals with SLE may suffer from organ damage caused by excessive production of multiple autoantibodies and subsequent deposition of immune complexes composed of antibodies and antigens in various organs, including the kidneys [625]